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Brent Hill, Ph.D.

Associate Professor

bhill@uca.edu

LSC 150

(501) 450-5925

Ph.D., University of Missouri, Columbia, 2000. Vertebrate Physiology

Research Specialty: Cardiovascular physiology/pharmacology/sex hormones

Advising Specialty: Pre-Veterinary

B.A., Biology, Luther College M.S., Veterinary Physiology & Pharmacology, College of Veterinary Medicine, Iowa State University Ph.D., Medical Physiology, College of Medicine, University of Missouri

Research Specialty: Cardiovascular  physiology/pharmacology/sex hormones

The loss of estradiol (e.g., estrogen) with menopause causes a dramatic rise in the development of coronary heart disease. In fact, atherosclerosis of the coronary arteries (i.e., coronary artery/heart disease) is the number one killer of postmenopausal women and is considered, in part, an age-related disease. It has been speculated that the protective effects of estradiol against coronary artery disease may partially be due to theaction of its metabolites. The overall goal of my research is to understand how the metabolites of estradiol may protect against coronary artery disease. As previously established for estradiol, the protective effects of the metabolites will likely be due to its actions on (1) coronary artery tone, and/or (2) smooth muscle cell proliferation. Our objective is to evaluate the most biologically efficacious estradiol metabolites, 2-hydroxyestradiol and 2-methoxyestradiol, at the molecular/cellular level and then determine if these metabolite-induced effects are present at the tissue level. Remarkably, almost nothing is known about the action of these estradiol metabolites on the vasculature; most of the limited data on their influence is related to its antimitogenic effect on cancer cells (e.g., breast cancer). Please contact me if you desire to be an undergraduate researcher or pursue a graduate (M.S.) degree in my laboratory.