Kari Naylor, Ph.D.
Ph.D., University of California, Davis, 2004.
Research Specialty:Mitochondrial dynamics
Advising Specialty: Pre-Optometry
My research focuses on understanding how mitochondrial structure affects mitochondrial function. Specifically we look at the proteins that maintain the tubular structure of the mitochondria in the model system Saccharomyces cerevisae also known as budding yeast. We use a variety of genetic, biochemical, microbiological, molecular and microscopy techniques. Currently our work is focusing on the mechanism of mitochondrial fission. To understand fission we must understand the function of the proteins involved so we are taking a structure-function approach by analyzing mutants and their fission activity. Additionally, using the confocal microscope we will be analyzing the assembly and formation of protein complexes and targeting to the mitochondria by literally taking movies of yeast cells.The newest project in the lab uses Dictyostelium discoideum. We are using this slime mold model system to further explore the mechanism of mitochondrial fission and to compare the mechanisms between different organisms.Interacts with Assembled Dnm1 to Promote Mitochondrial Fissionhttp://www.jbc.org/cgi/reprint/281/4/2177The WD repeat protein, Mdv1, functions as a molecular adaptor by interacting with Dnm1 and Fis1 during mitochondrial fissionhttp://www.jcb.org/cgi/reprint/158/3/445